One of my projects last year was the same as Justin's layout. Networker 7.6.x, 
with multiple Data Domains and VCE vBlocks.
The networker server is safeguarded by SRM/recoverpoint to allow for speedy 
failover to the secondary site.
All on 1Gb network, so that makes it nice and quick.
No exceptional issues apart from the normal ones in a physical server 
environment.
Andy F

> Date: Mon, 24 Jun 2013 13:25:36 +0000
> From: Justin.Roberts2 AT GE DOT COM
> Subject: Re: [Networker] networker server as VM
> To: NETWORKER AT LISTSERV.TEMPLE DOT EDU
> 
> Our entire environment is running on virtual machines backing up to Data 
> Domain.  We haven't seen any issues with them being virtual and EMC has fully 
> supported them for us. 
> 
> -----Original Message-----
> From: EMC NetWorker discussion [mailto:NETWORKER AT LISTSERV.TEMPLE DOT EDU] 
> On Behalf Of Stanley R. Horwitz
> Sent: Wednesday, June 19, 2013 4:27 PM
> To: NETWORKER AT LISTSERV.TEMPLE DOT EDU
> Subject: Re: [Networker] networker server as VM
> 
> Dave,
> 
> Does EMC support deploying NetWorker in a virtual server environment? With 
> the heavy network bandwidth that backups typically require, as well as high 
> processor load, I couldn't imagine virtualizing a backup server in any 
> environment where there are more than just a few backup clients. It also 
> seems to me that hosting a virtualized backup server in the same VMware 
> complex that is being backed up amounts to putting all of one's eggs in a 
> single basket. What happens if the ESX server that host's the NetWorker 
> server crashes, or its storage crashes?
> 
> On Jun 19, 2013, at 2:10 PM, <dave2 AT CAMBRIDGECOMPUTER DOT COM<mailto:dave2 
> AT CAMBRIDGECOMPUTER DOT COM>> wrote:
> 
> Hi,
> 
> I was wondering what folks experience was with having their NetWorker server 
> configured as a VM?
> 
> 
> I'm specifically thinking about the need to have a local device for indexes 
> and bootstraps. How have you dealt with that in an all tape (or FC-only
> VTL) environment?