My clients run a mix of Microsoft Security Essentials and Immunet with 
ClamAV, and I'm running cwRsyncServer as rsyncd for use by BackupPC. I 
realized that the rsyncd service is likely causing an AV scan with each 
file access and that's a big performance hit on the client as it searches 
the whole disk for file changes. I see that I can add rsyncd.exe as an 
exception to the AV but doesn't that just prevent the scan when loading the 
rsyncd.exe file? What's needed to make file accesses by that program immune 
from scanning? (I expect that this answer will be different for every AV, 
and it would be useful to know what other AVs do, as I might switch AV 
products to facilitate this.)

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