On your client, in the DSM.OPT file you can use the EXCLUDE statement to specifically exclude certain files..example
Exclude "I:\...\*"
Exclude "J:\...\*"
Exclude "K:\...\*"
Exclude "L:\...\*"
Exclude "M:\...\*"
Exclude "N:\...\*"
Exclude "O:\...\*"
Exclude "P:\...\*"
Exclude.File "C:\Documents and Settings\administrator\NTUSER.DAT"
Exclude.File "C:\Documents and Settings\administrator \NTUSER.DAT"
Exclude.File "C:\Documents and Settings\administrator\ntuser.dat.LOG".
Hope this helps