You want to use OST without a doubt.. With optimized deduped replication you 
end up pushing almost nothing across the wire.. With VTL its a full rehydration 
on the source end before it gets replicated. I just spent several months 
testing this on Data Domain and Quantum DXi. The only caveat is Data Domain has 
no path to tape so to push it to tape from the data domain the data is going 
back up thru the media server stack and out to tape - which IMHO is no big deal 
- that is what your media servers are designed and sized to do.

But as far as replication goes, nothing comes close to using OST for this.. I 
saw 100gb backups that resulted in only like 2gb having to be moved across the 
wire. The only downside is you must use storage lifecycle policies and I'm not 
too impressed with Netbackup's implementation of these. (and you still need 
vault to move from data domain out to tape unless you feel like scripting this, 
which is doable.)

If you go back in time to what VTL was born from, it really was a jury-rig 
approach to doing backups to disk. OST bridges this gap.

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