What's the primary purpose of replicating data off-site? DR or long term retention? If it's latter, then you would try CloudBoost, which is fully integrated with Avamar/NW/NBU today. It allows backup data to be sent to public/private service providers.
And next year, DD will have a feature called Cloud Tiering. DD will be able to natively use blob storage on cloud as an extension and based on the defined policies, data will be moved to cloud tier in deduplicated form (no need to rehyradate and dedupe again), regardless of the backup software being used.