Hi Bro,

I dont think youi can directly upgrade to 4.5..First you need to upgrade your 
4.5 netbackup environment to 5.x then from 5.x you will need to upgrade it to 
6.0..Once you upgrade it to 5.x run the NBCC utility to make sure there are no 
inconsistencies within the environment once you are done with that you can 
upgrade yur netbackup environment to 6.0.

Let me know if you have any queries regarding the same

Thanks 

AjW

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