We have this problem with two clients running on Windows 2k SP3 too. The 
failing directories are the same.
Other clients with W2K which were newly installed in Networker are running 
fine. These clients are no VMs.

We have never seen this issue when we are doing full saves of the clients just 
with incrementals and even the incrementals are running fine on some days.

We upgraded the clients from NW 7.0.x to 7.5.3 SP3 which is also running on our 
NW server.

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