I kinda figured that would be one of the first questions I was asked. I was 
attempting to 'keep it simple' so as I mentioned, I configured it from the GUI, 
but in searching the mail archives I see that manually editing the conf file 
seems like the way to go. Here's what I have so far:

$Conf{RsyncShareName} = [
  '/home'
];

$Conf{BackupFilesExclude} = {
  '/home/*/Downloads' => [
    ''
  ]
};

It looks like I need to change it to:

$Conf{BackupFilesExclude} = {
  '/home' => [
    '',
    '/*/Downloads'
  ]
};

Is that correct?

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