I have 6 key servers that I create backupsets for (Tuesday and Thursday). 
Depending on your media (mine is DLT 40/80) and your DR site hardware 
(availability of drives to use), I would suggest the more servers you can put 
on a backupset the better. These sets are great to have running while you build 
your TSM server and restore your DB. I mostly use them for NT4 systems, but 
will be working more with them and Win2000 servers. NT4 was easy to do a bare 
metal compared to WIN2000. 

I ran into a few hung sessions while creating some backupsets with my web 
servers (alot of small files). I ran a selective backup on those troubled nodes 
and this seemed to fix this. 

server is 4.2.1.12 on Win2000AS

Joe