Fast PCI bus's, you'll want multiple channels of it for other IO that must pass 
through the system

CPU should at minimum be quadcore or better.  If you need to use multiple 
CPU's, so be it, but buying more cores will help you alleviate the various 
tiering prices when you go with the Enterprise NBU server licenses.

RAM should be at least 16GB or more.  If you are going to do dedupe, you'll 
need even more.  1GB of RAM per 1TB of data that is stored in the dedupe store.

At the end of the day, many 2U and larger servers meet this goal.  Stick to 
Intel procs in most cases.  Though lots of testing within Symantec does use AMD 
too, at least from the product management side.

Think about what you may install in this server...  10GbE, FC HBA, perhaps 
redundant cards? SCSI, SAS RAID card, etc..  Make sure your server could 
accommodate that, and you're usually golden.

Technically Symantec does have a tuning guide that helps you size the server 
based on client count, file count, etc..  But that only gets you so far.

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