Gidday, I've been running synthetics for nearly two years now to backup about 
3/3.5 TBs and have to say has generally run extremely well.

Within the same policy I have 3 schedules.

The first is an ad-hoc full - I used this to create the first full backup, and 
on the very few occasions when the synthetic has stuffed up and I needed to 
start again.  It has a 1 month retention.

Second is a daily differential that runs every three hours and goes to disc.  
They have a two week retention period.

Lastly, I have the synthetic full backup.  Runs every saturday and also has a 1 
month retention.

Like I said, it occasionaly stuffs up, but works 99% of the time, and appears 
to run 3 to 4 times faster than a traditional full.

I HIGHLY recommend it.

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