In most cases you do the following:
Any real-time scanning you disable on any and all EXE's that pertain to backups 
apps, and Db engines
You also exclude any directory that pertains to the backup app and Db directory
Some AV programs can scan running processes, well you want to exclude those too.

Outside of that, what are you experiencing that your current exclusions are not 
helping?  
Can you use a file watch tool to see what is getting accessed and by what app?  
e.g. sysinternals has tools for this.

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