Hi Saravanan,
One way this issue can be reproduced, is I rename a file the TSM API
depends on:

C:\Program Files\Common Files\Tivoli\TSM\api64>rename dscenu.txt
dscenu.txt.sav

C:\Program Files\Tivoli\TSM\domino>domdsmc query adsm

IBM Tivoli Storage Manager for Mail:
Data Protection for Lotus Domino
Version 5, Release 5, Level 1.0
(C) Copyright IBM Corporation 1999, 2008. All rights reserved.

 ACD5412W An error was encountered with Tivoli Storage Manager API
initialization, rc = 610.
Examine the dsierror.log for more information or determine if the TSM API
is installed properly.
 Warning! Error initializing the connection to the TDP library

Could not connect to the Adsm server


I recommend that you uninstall/reinstall Domino:Mail. If this doesn't work,
call IBM Support.
Frank Ramke
TSM Development