Speaking strictly from the Data Domain perspective, you may have issues fitting such a database into a single box unless you are running the 990 or a GDA.
The only feasible solution with manageable backup window would be a split mirror backup on the array or VxVM, then depending on the backup schedule, you may need awfully lot of tape drives or a really high-end Data Domian. If you're planning to have daily fills then you need to design a system capable of pushing circa 20TB/hr
I am not sure about the change rate in your case, but in general I would be hesitant to backup such a large DB with one single monthly full: in case of recovery it will take unreasonably long time even with cumulative incremental backups, which are quite effective in Oracle.
WBR, Mikhail
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