It depends. 

Only for NetWorker backups NW will use its own format. In fact, it is the same 
no matter which media is used for backups. That's why one can use the same 
mechanisms in both places (tools like 'scanner' work the same way). There is no 
more change when moving it 

For NDMP backups, it is different as only NDMP writes the data - NW will, 
actually it can't, embed meta data. That's why you should sent NDMP data to 
separate tape pools. You also need NDMP specific save/recover/clone commands. 
Additionally, NDMP only supports local backup to tape (unless you add a NDMP 
tape driver on a storage node or use another NDMP filer of the same 
manufacturer).
However, since NW 7.2? you may use NW's embeed Data Storage Agent (DSA) which 
'wraps' the NDMP data into 'normal' NW backup data packages so that the first 
rule will apply again. Assuming your network  being fast enough, DSA backups 
are the better and more flexible alternative.

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